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2011 Department Newsletter



2011

Employment at BioChem

The Department of Biological Chemistry seeks applications from outstanding junior investigators for a tenure-track position as an Assistant Professor. See Job Posting

Nichols Receives Teaching Award

Congratulations to Associate Professor Ruthann Nichols, recipient of the 2011-2011 Endowment for the Basic Sciences Teaching Award in Biological Chemistry. This award recognizes Dr. Nichols’ long and distinguished career as an educator and mentor, especially her outstanding teaching in Biol Chem 212 and her dedication to undergraduate mentoring in the laboratory.


Paul Weinhold Retires

Congratulations to Dr. Paul Weinhold, who earlier this month gave his final lecture in the UM medical student pre-clinical curriculum following a career spanning six decades. Dr. Roger Grekin, Professor of Internal Medicine and Associate Chief of Staff for Research and Development in the Veterans' Affairs Healthcare System was there to mark the occasion. Dr. Grekin writes, “Paul Weinhold joined the Biological Chemistry faculty in 1965 after completing a postdoctoral fellowship at Harvard. He established a highly successful laboratory at the VA Medical Center and became an internationally recognized expert in the area of phospholipid metabolism. He maintained funding from both the NIH and the VA throughout his investigative career. Paul has made major contributions to medical student teaching. He served as a laboratory instructor and then as a lecturer in the medical student Biochemistry course, and he directed the course from 1991 to 1992. When the curriculum was revised in 1992, he became the director of the Cells and Tissues sequence and served in that role for 20 years. He has given the metabolism lectures for over 30 years, and has been an important contributor to medical student education for 47 years. He won the Kaiser award, the Medical School’s highest award for excellence in teaching, in 1994.” Congratulations, Paul!

News from the Labs

December brought a round of doctoral defenses and three of BioChem’s graduate students now proudly sport their new initials. First up was Corissa L. Lamphear whose dissertation Molecular Recognition of Substrates by Protein Farnesyltransferase and Geranylgeranyltransferanse-I was overseen by mentor Carol Fierke. Dr. Lamphear will be teaching General Chemistry here at the University of Michigan in January and continuing her work on protein prenyltransferase specificity in Dr. Fierke’s lab. Then, she plans on pursuing post-doctoral research opportunities. Next up was Valentin F. Cracan. His thesis Structure, Function and Metabolic Roles of IcmF-a Fusion Between the Radical B12 Enzyme and its G-protein Chaperone was written while in Ruma Banerjee’s lab. Dr. Cracan is headed over to Harvard’s Medical School to pursue postdoctoral studies with Dr. Vamsi Mootha. The Mootha lab combines biochemistry, genomics, and computational techniques to investigate mitochondrial disorders. Finally, Dave A. Pai, who studied with David Engelke defended his work, writing on Spatial coordination of tRNA genes. Dr. Pai plans to pursue postdoctoral research in molecular biology and nucleic acid biochemistry. Our deepest congratulations go out to them all.

News & Announcements

Professor Ursula Jakob has published Using quantitative redox proteomics to dissect the yeast redoxome in the December 2, 2011 issue of the Journal of Biological Chemistry. Her studies provide experimental evidence that the ability of protein thiols to react to changing peroxide levels is likely governed by both thermodynamic and kinetic parameters, making predicting thiol modifications challenging and de novo identification of peroxide sensitive protein thiols indispensable. Read the abstract for her paper here PMID: 21976664

Graduate student Chase Weidmann is listed listed as first author on Drosophila Pumilio Protein Contains Multiple Autonomous Repression Domains That Regulate mRNAs Independently of Nanos and Brain Tumor, written with his mentor Aaron Goldstrohm. Their findings suggest that PUF proteins have evolved new regulatory functions through protein sequences appended to their conserved PUF repeat RNA-binding domains. Read the abstract for this Molecular and Cellular Biology paper here PMID: 22064486

Professors Jason Gestwicki and Georgios Skiniotis Have collaborated with graduate students in the ChemBio grad program and published Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK) in a recent isssue of Cell Stress Chaperones. Their studies suggest that DnaK oligomers are composed of ordered multimers that are functionally distinct from monomeric DnaK. Thus, oligomerization of DnaK might be an important step in chaperone cycling. Read the abstract here PMID: 22076723


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