News from the Labs
December brought a round of doctoral defenses and three of BioChem’s graduate students now proudly sport their new initials. First up was Corissa L. Lamphear whose dissertation Molecular Recognition of Substrates by Protein Farnesyltransferase
and Geranylgeranyltransferanse-I was overseen by mentor Carol Fierke. Dr. Lamphear will be teaching General Chemistry here at the University of Michigan in January and continuing her work on
protein prenyltransferase specificity in Dr. Fierke’s lab. Then, she plans on pursuing post-doctoral research opportunities. Next up was Valentin F. Cracan. His thesis Structure, Function and Metabolic Roles of IcmF-a Fusion Between the Radical B12 Enzyme and its G-protein Chaperone was written while in Ruma Banerjee’s lab.
Dr. Cracan is headed over to Harvard’s Medical School to pursue postdoctoral studies with Dr. Vamsi Mootha. The Mootha lab combines biochemistry, genomics, and computational techniques to investigate mitochondrial disorders. Finally, Dave A. Pai, who studied with David Engelke defended his work, writing on Spatial coordination of tRNA genes. Dr. Pai plans to pursue postdoctoral research in molecular biology and nucleic acid biochemistry. Our deepest congratulations go out to them all.




Congratulations to Associate Professor Ruthann Nichols, recipient of the 2011-2011 Endowment for the Basic Sciences Teaching Award in Biological Chemistry. This award recognizes Dr. Nichols’ long and distinguished career as an educator and mentor, especially her outstanding teaching in Biol Chem 212 and her dedication to undergraduate mentoring in the laboratory.
December 2, 2011 issue of the Journal of Biological Chemistry. Her studies provide experimental evidence that the ability of protein thiols to react to changing peroxide levels is likely governed by both thermodynamic and kinetic parameters, making predicting thiol modifications challenging and de novo identification of peroxide sensitive protein thiols indispensable. Read the abstract for her paper here
Autonomous Repression Domains That Regulate mRNAs Independently of Nanos and Brain Tumor, written with his mentor Aaron Goldstrohm. Their findings suggest that PUF proteins have evolved new regulatory functions through protein sequences appended to their conserved PUF repeat RNA-binding domains. Read the abstract for this Molecular and Cellular Biology paper here